Requirement of B Cells for Generating CD4+T Cell Memory

T Cell Memory + Requirement of B Cells for Generating CD

Requirement of B cells for generating CD4+ T cell memory.

B cells can influence T cell responses by directly presenting Ag or by secreting Ab that binds to Ag to form immunogenic complexes. Conflicting evidence suggests that persisting Ag-Ab complexes propagate long-term T cell memory; yet, other data indicate that memory cells can survive without specific Ag or MHC. In this study, the roles of B cells and Ag-Ab complexes in T cell responses to lympho...

Memory + Requirement of B Cells for Generating CD

T Cell Memory + Requirement of B Cells for Generating CD 4

Requirement for autophagy in the long-term persistence but not initial formation of memory B cells.

Autophagy is required for the long-term maintenance of Ag-specific memory B cells. However, whether autophagy is also important for the initial formation of memory B cells remains unclear. In this study, we show that newly generated memory B cells do not display active autophagy but are capable of forming Ab-secreting cells after rechallenge with Ags. Increases in autophagy took place over time...